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1

New and emerging technologies for genetic toxicity testing

Anthony M. Lynch, Jennifer C. Sasaki, Rosalie Elespuru, David Jacobson-Kram, Véronique Thybaud, Marlies De Boeck, Marilyn J. Aardema, Jiri Aubrecht, R. Daniel Benz, Stephen D. Dertinger, George R. Dou

Journal:

Environmental and Molecular Mutagenesis

Année:

2011

Langue:

english

Fichier:

PDF, 350 KB

english, 2011

2

Adverse effects in wild fish living downstream from pharmaceutical manufacture discharges

Wilfried Sanchez, William Sremski, Benjamin Piccini, Olivier Palluel, Emmanuelle Maillot-Maréchal, Stéphane Betoulle, Ali Jaffal, Sélim Aït-Aïssa, François Brion, Eric Thybaud, Nathalie Hinfray, Jean-

Journal:

Environment International

Année:

2011

Langue:

english

Fichier:

PDF, 833 KB

english, 2011

3

Follow-up actions from positive results of in vitro genetic toxicity testing

Kerry L. Dearfield, Véronique Thybaud, Michael C. Cimino, Laura Custer, Andreas Czich, James S. Harvey, Susan Hester, James H. Kim, David Kirkland, Dan D. Levy, Elisabeth Lorge, Martha M. Moore, Glady

Journal:

Environmental and Molecular Mutagenesis

Année:

2011

Langue:

english

Fichier:

PDF, 405 KB

english, 2011

4

Use of ISFETs for 24 h pH monitoring in the gastrooesophageal tract

L. Thybaud, C. Depeursinge, D. Rouiller, G. Mondin, A. Grisel

Journal:

Sensors and Actuators B: Chemical

Année:

1990

Langue:

english

Fichier:

PDF, 719 KB

english, 1990

5

Multichannel ISFET catheter for temporal and spatial pH variation studies in the stomach over 24 hours

L. Thybaud, C. Depeursinge, A. Grisel, C. Emde, D. Armstrong, F. Viani

Journal:

Sensors and Actuators B: Chemical

Année:

1992

Langue:

english

Fichier:

PDF, 358 KB

english, 1992

6

Reactivity of antimony mixed halides for the fluorination of tetrachlorethene (PCE) in liquid phase

S. Brunet, C. Batiot, P. Moriceau, N. Thybaud

Journal:

Journal of Molecular Catalysis A: Chemical

Année:

1999

Langue:

english

Fichier:

PDF, 109 KB

english, 1999

7

Induction of Fish Vitellogenin and Alterations in Testicular Structure: Preliminary Results of Estrogenic Effects in Chub (Leuciscus cephalus)

P. Flammarion, F. Brion, M. Babut, J. Garric, B. Migeon, P. Noury, E. Thybaud, X. Palazzi, C. R. Tyler

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 198 KB

english, 2000

8

Optimum associations of tester strains for maximum detection of mutagenic compounds in the Ames test

D. Bonneau, V. Thybaud, C. Melcion, F. Bouhet, A. Cordier

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Année:

1991

Langue:

english

Fichier:

PDF, 590 KB

english, 1991

9

SFTG international collaborative study on in vitro micronucleus test: III. Using CHO cells

Marilyn J. Aardema, Ronald D. Snyder, Carol Spicer, Katyayini Divi, Takeshi Morita, Robert J. Mauthe, David P. Gibson, Sandra Soelter, Patrick T. Curry, Veronique Thybaud, Giocondo Lorenzon, Daniel Ma

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

2006

Langue:

english

Fichier:

PDF, 234 KB

english, 2006

10

SFTG international collaborative study on in vitro micronucleus test: I. General conditions and overall conclusions of the study

Elisabeth Lorge, Veronique Thybaud, Marilyn J. Aardema, Jo Oliver, Akihiro Wakata, Giocondo Lorenzon, Daniel Marzin

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

2006

Langue:

english

Fichier:

PDF, 684 KB

english, 2006

11

Effects of ethylene glycol ethers on the reproduction of Ceriodaphnia dubia

J Devillers, A Chezeau, V Poulsen, E Thybaud

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 67 KB

english, 2003

12

Identification of Synthetic Steroids in River Water Downstream from Pharmaceutical Manufacture Discharges Based on a Bioanalytical Approach and Passive Sampling

Creusot, Nicolas, Aït-Aïssa, Selim, Tapie, Nathalie, Pardon, Patrick, Brion, François, Sanchez, Wilfried, Thybaud, Eric, Porcher, Jean-Marc, Budzinski, Hélène

Journal:

Environmental Science & Technology

Année:

2014

Langue:

english

Fichier:

PDF, 2.01 MB

english, 2014

13

Ecotoxicologie du lindane et de la deltaméthrine en milieu aquatique; Ecotoxicology of lindane and deltamethrin in aquatic environments;

Journal:

Revue des sciences de l'eau

Année:

1990

Fichier:

PDF, 591 KB

1990

14

Mouse lymphoma workshop: Victoria, British Columbia, Canada, March 27, 1996 Protocol issues regarding the use of the microwell method of the mouse lymphoma assay

Toshio Sofuni, Philip Wilcox, Hiroyasu Shimada, Julie Clements, Masamitsu Honma, Donald Clive, Michael Green, Veronique Thybaud, Richard H.C. San, Barry M. Elliott, Lutz Müller

Journal:

Environmental and Molecular Mutagenesis

Année:

1997

Langue:

english

Fichier:

PDF, 42 KB

english, 1997

15

Kinetics of induction of DNA damage and lacZ gene mutations in stomach mucosa of mice treated with β-propiolactone and N-methyl-N′-nitro-N-nitrosoguanidine, using single-cell gel electrophoresis and MutaTMMouse models

Dominique Brault, Dominique Renault, Françoise Tombolan, Véronique Thybaud

Journal:

Environmental and Molecular Mutagenesis

Année:

1999

Langue:

english

Fichier:

PDF, 93 KB

english, 1999

16

Laboratory variability does not preclude identification of biological functions impacted by hydroxyurea

Arne Müller, Eric Boitier, Ting Hu, Gregory J. Carr, Anne-Céline Le Fèvre, Jean-Pierre Marchandeau, Manoli Flor, Felicia Jefferson, Marilyn J. Aardema, Véronique Thybaud

Journal:

Environmental and Molecular Mutagenesis

Année:

2005

Langue:

english

Fichier:

PDF, 430 KB

english, 2005

17

Application of toxicogenomics to genetic toxicology risk assessment

Véronique Thybaud, Anne-Céline Le Fevre, Eric Boitier

Journal:

Environmental and Molecular Mutagenesis

Année:

2007

Langue:

english

Fichier:

PDF, 444 KB

english, 2007

18

Strategies for the follow-up of positive results in the in vitro genotoxicity assays—An international collaborative initiative

B. Bhaskar Gollapudi, Véronique Thybaud, James H. Kim, Michael Holsapple

Journal:

Environmental and Molecular Mutagenesis

Année:

2011

Langue:

english

Fichier:

PDF, 47 KB

english, 2011

19

Need and potential value of the Pig-ain vivo mutation assay—A hesi perspective

Maik Schuler, B. Bhaskar Gollapudi, Véronique Thybaud, James H. Kim

Journal:

Environmental and Molecular Mutagenesis

Année:

2011

Langue:

english

Fichier:

PDF, 110 KB

english, 2011

20

An index of effluent aquatic toxicity designed by partial least squares regression, using acute and chronic tests and expert judgements

ÉRIC Vindimian, Jeanne Garric, Patrick Flammarion, Éric Thybaud, Marc Babut

Journal:

Environmental Toxicology and Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 71 KB

english, 1999

21

Modeling explicitly and mechanistically median lethal concentration as a function of time for risk assessment

Vincent Bonnomet, Cédric Duboudin, Hélène Magaud, Eric Thybaud, Eric Vindimian, Bernard Beauzamy

Journal:

Environmental Toxicology and Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 141 KB

english, 2002

22

Two-step purification method of vitellogenin from three teleost fish species: rainbow trout (Oncorhynchus mykiss), gudgeon (Gobio gobio) and chub (Leuciscus cephalus)

François Brion, Françoise Rogerieux, Patrice Noury, Bernard Migeon, Patrick Flammarion, Eric Thybaud, Jean-Marc Porcher

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

2000

Langue:

english

Fichier:

PDF, 551 KB

english, 2000

23

Toxicité aigüe et bioconcentration du lindane et de la deltaméthrine par les tetards deRana temporariaet les gambusies (Gambusia affinis)

Journal:

Année:

1990

Fichier:

PDF, 553 KB

1990

24

Use of scanning cytometry in studying bradykinin binding in MRC-5 cells

M. Maratrat, N. Munoz, I. Gravier, V. Thybaud, A. Crespo

Journal:

Cell Biology and Toxicology

Année:

1994

Langue:

english

Fichier:

PDF, 395 KB

english, 1994

25

Fixationsprinzipien des zementlosen modularen Hüftrevisionsschaftes Revitan

B. Fink, M. Fuerst, M. Hahn, L. Thybaud, H.-P. Sieber, G. Delling

Journal:

Der Unfallchirurg

Année:

2005

Langue:

german

Fichier:

PDF, 1.27 MB

german, 2005

26

Time Course Transformations and Fate of Mercury in Aquatic Model Ecosystems

Emmanuel Tessier, Rosa C. Rodriguez Martin-Doimeadios, David Amouroux, Anne Morin, Christian Lehnhoff, Eric Thybaud, Eric Vindimian, Olivier F. X. Donard

Journal:

Water, Air & Soil Pollution

Année:

2007

Langue:

english

Fichier:

PDF, 564 KB

english, 2007

27

Organochlorine contaminants in common tern (Sterna hirundo) eggs and young from the river Rhine area (France)

L. Castillo, E. Thybaud, T. Caquet, F. Ramade

Journal:

Bulletin of Environmental Contamination and Toxicology

Année:

1994

Langue:

english

Fichier:

PDF, 318 KB

english, 1994

28

Absorption and elimination of lindane byAsellus aquaticus(Crustacea, Isopoda)

E. Thybaud, S. Le Bras

Journal:

Bulletin of Environmental Contamination and Toxicology

Année:

1988

Langue:

english

Fichier:

PDF, 214 KB

english, 1988

29

Organ-specific, carcinogenic dibenzo[c, g]carbazole derivatives: discriminative response in S. typhimurium TA100 mutagenesis modulated by subcellular fractions of mouse liver

F. Périn, D. Valéro, V. Thybaud-Lambay, M.J. Plessis, F. Zajdela

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

1988

Langue:

english

Fichier:

PDF, 796 KB

english, 1988

30

Automation of the SOS chromotest: validation and comparison with the literature data

M.C. Diot, V. Thybaud, C. Melcion, A. Cordier

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Année:

1990

Langue:

english

Fichier:

PDF, 85 KB

english, 1990

31

Use of the SOS chromotest in genetic toxicology: comparison with the Ames test with 94 compounds

V. Thybaud, C. Melcion, A. Cordier

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Année:

1990

Langue:

english

Fichier:

PDF, 94 KB

english, 1990

32

Carcinogen/ noncarcinogen in mouse hepatocyte micronucleus test

V. Benning, J.P. Pasquet, C. Thybaud, C. Melcion, A. Cordier

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Année:

1992

Langue:

english

Fichier:

PDF, 83 KB

english, 1992

33

Tissue-specific induction of mutations by acute oral administration of N-methyl-N′-nitro-N-nitrosoguanidine and β-propiolactone to the Muta™Mouse: preliminary data on stomach, liver and bone marrow

Dominique Brault, Carine Bouilly, Dominique Renault, Véronique Thybaud

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Année:

1996

Langue:

english

Fichier:

PDF, 343 KB

english, 1996

34

Role of the uvr gene in the SOS function inducing activity of two tryptophan pyrolysis products, Trp-P-1 and Trp-P-2, in Escherichia coli K12

V Thybaud-Lambay, F Decloitre, Y.A Courtois

Journal:

Mutation Research Letters

Année:

1986

Langue:

english

Fichier:

PDF, 258 KB

english, 1986

35

Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling

Anne-Celine Le Fevre, Eric Boitier, Jean-Pierre Marchandeau, Alain Sarasin, Veronique Thybaud

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

2007

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2007

36

(Tri)Butyltin biotic degradation rates and pathways in different compartments of a freshwater model ecosystem

Emmanuel Tessier, David Amouroux, Anne Morin, Lehnhoff Christian, Eric Thybaud, Eric Vindimian, Olivier F.X. Donard

Journal:

Science of The Total Environment

Année:

2007

Langue:

english

Fichier:

PDF, 538 KB

english, 2007

37

Early cellular effects of Trp-P-1 on adult rat hepatocytes in primary culture

V. Thybaud-Lambay, M. Martin, F. Decloitre

Journal:

Chemico-Biological Interactions

Année:

1985

Langue:

english

Fichier:

PDF, 433 KB

english, 1985

38

P XV.17 - P XV.17 Kinetics of detection of β-proplolactone and N-methyl-N′-nitro-N-nitrosoguanidine genotasic effects in mouse gastric mucosa using single gel cell electrophoresis assay and Muta™″ mouse assay

Dominique Brault, Dominique Renault, Françoise Tombolan, Véronique Thybaud

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

1997

Langue:

english

Fichier:

PDF, 134 KB

english, 1997

39

P XV.13 - P XV.13 Role of DNA-adduct formation and cell proliferation in the induction of gene mutations by 5,9-dimethyl-dibenzocarbazole in Muta™″ Mouse liver

Françoise Tombolan, Dominique Brault, Dominique Renault, François Périn, Odette Périn-Roussel, Danièle Taras, Véronique Thybaud

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

1997

Langue:

english

Fichier:

PDF, 232 KB

english, 1997

40

P XV.15 - P XV.15 Tissue-specific mutagenicity of 7H-dibenzo[c,g]carbazole and two derivatives in Muta™″ Mouse following topical application

Dominique Renault, Dominique Brault, Françoise Tombolan, François Périn, Véronique Thybaud

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

1997

Langue:

english

Fichier:

PDF, 116 KB

english, 1997

41

O XIX B.3 - O XIX B.3 How new in vivo assays will help in the assessment of genotoxicity risk

Véronique Thybaud

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

1997

Langue:

english

Fichier:

PDF, 118 KB

english, 1997

42

Lack of induction of gene mutations in Muta™ Mmouse transgenic mice liver seven days after treatment by two promutagens, 4-aminobiphenyl and 4-aminophenol

V. Thybaud, D. Brault, Rhône-Poulenc Rorer

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Année:

1996

Langue:

english

Fichier:

PDF, 78 KB

english, 1996

43

Environmental risk assessment: A critical approach of the European TGD in an in situ application

I. Guérit, G. Bocquené, A. James, E. Thybaud, C. Minier

Journal:

Ecotoxicology and Environmental Safety

Année:

2008

Langue:

english

Fichier:

PDF, 740 KB

english, 2008

44

In vivo transgenic mutation assays

Véronique Thybaud, Stephen Dean, Takehiko Nohmi, Johan de Boer, George R. Douglas, Barry W. Glickman, Nancy J. Gorelick, John A. Heddle, Robert H. Heflich, Iain Lambert, Hans-Jörg Martus, Jon C. Mirsa

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

2003

Langue:

english

Fichier:

PDF, 114 KB

english, 2003

45

The autoradiographic test for unscheduled DNA synthesis: a sensitive assay for the detection of DNA repair in the HepG2 cell line

Isabelle Valentin-Severin, Véronique Thybaud, Anne-Marie Le Bon, Jean-Claude Lhuguenot, Marie-Christine Chagnon

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

2004

Langue:

english

Fichier:

PDF, 107 KB

english, 2004

46

SFTG international collaborative study on in vitro micronucleus test: V. Using L5178Y cells

Jo Oliver, Jean-Roch Meunier, Takumi Awogi, Azeddine Elhajouji, Marie-Claude Ouldelhkim, Nicole Bichet, Veronique Thybaud, Giocondo Lorenzon, Daniel Marzin, Elisabeth Lorge

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

2006

Langue:

english

Fichier:

PDF, 208 KB

english, 2006

47

SFTG international collaborative study on in vitro micronucleus test: II. Using human lymphocytes

M. Gillian Clare, Giocondo Lorenzon, Leslie C. Akhurst, Daniel Marzin, Joost van Delft, Regina Montero, Alain Botta, Arma Bertens, Serena Cinelli, Véronique Thybaud, Elisabeth Lorge

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

2006

Langue:

english

Fichier:

PDF, 263 KB

english, 2006

48

Strategy for genotoxicity testing: Hazard identification and risk assessment in relation to in vitro testing

V. Thybaud, M. Aardema, J. Clements, K. Dearfield, S. Galloway, M. Hayashi, D. Jacobson-Kram, D. Kirkland, J.T. MacGregor, D. Marzin, W. Ohyama, M. Schuler, H. Suzuki, E. Zeiger

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

2007

Langue:

english

Fichier:

PDF, 738 KB

english, 2007

49

Relevance and follow-up of positive results in in vitro genetic toxicity assays: An ILSI-HESI initiative

Véronique Thybaud, Marilyn Aardema, Daniel Casciano, Vicki Dellarco, Michelle R. Embry, B. Bhaskar Gollapudi, Makoto Hayashi, Michael P. Holsapple, David Jacobson-Kram, Peter Kasper, James T. MacGrego

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

2007

Langue:

english

Fichier:

PDF, 172 KB

english, 2007

50

Cytosine arabinoside, vinblastine, 5-fluorouracil and 2-aminoanthracene testing in the in vitro micronucleus assay with L5178Y mouse lymphoma cells at Sanofi Aventis, with different cytotoxicity measurements, in support of the draft OECD Test Guideline on In Vitro Mammalian Cell Micronucleus Test

Olivier Cariou, Nathalie Laroche-Prigent, Sandrine Ledieu, Isabelle Guizon, Françoise Paillard, Véronique Thybaud

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

2010

Langue:

english

Fichier:

PDF, 931 KB

english, 2010